Listar por autor "Escors Murugarren, David"

Mostrando ítems 1-20 de 24

    • CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer 

      Martín Sánchez, Esperanza; Mendaza Lainez, Saioa Upna; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Blanco Luquin, Idoia; Córdoba Iturriagagoitia, Alicia; Vicente García, Francisco; Pérez Janices, Noemi; Escors Murugarren, David; Megías, Diego (Impact Journals, 2017)   Artículo / Artikulua  OpenAccess
      The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation ...

    • Circulating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck cancer 

      Arrazubi, Virginia; Goñi Irigoyen, Saioa Upna Orcid; González Borja, Iranzu; Hernández García, Irene; Arasanz Esteban, Hugo; Pérez Sanz, Jairo; Bocanegra Gondán, Ana Isabel; Kochan, Grazyna; Escors Murugarren, David; Ruiz de Azúa, Yerani; Elizalde, Jesús María; Viúdez, Antonio; Vera García, Ruth (Wiley, 2023)   Artículo / Artikulua
      Background: Identification of predictive biomarkers to Immune checkpoint inhibitors (ICIs) in head and neck cancer (HNSCC) is an unmet need. Methods: This was a prospective observational study including 25 patients with ...

    • Clinical landscape of LAG-3-targeted therapy 

      Chocarro, Luisa Upna Orcid; Blanco, Ester; Arasanz Esteban, Hugo; Fernández Rubio, Leticia; Bocanegra Gondán, Ana Isabel; Echaide Górriz, Míriam; Garnica, Maider; Ramos, Pablo; Fernández Hinojal, Gonzalo; Vera García, Ruth; Kochan, Grazyna; Escors Murugarren, David (Elsevier, 2022)   Artículo / Artikulua  OpenAccess
      Lymphocyte-activated gene 3 (LAG-3) is a cell surface inhibitory receptor and a key regulator of immune homeostasis with multiple biological activities related to T-cell functions. LAG-3 is considered a next-generation ...

    • Contribution of systemic T cell immunity to clinical efficacy of anti-PD-L1/PD-1 immunotherapies in lung cancer 

      Zuazo Ibarra, Miren Upna Orcid (2020)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Un alto porcentaje de pacientes con cáncer de pulmón resistentes a terapias convencionales son refractarios a la inmunoterapia con anticuerpos bloqueadores de la interacción PD-L1/PD-1. En la presente tesis doctoral se ha ...

    • Cutting-edge CAR engineering: beyond T cells 

      Chocarro, Luisa Upna Orcid; Blanco, Ester; Fernández Rubio, Leticia; Arasanz Esteban, Hugo; Bocanegra Gondán, Ana Isabel; Echaide Górriz, Míriam; Garnica, Maider; Ramos, Pablo; Piñeiro Hermida, Sergio; Vera García, Ruth; Kochan, Grazyna; Escors Murugarren, David (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Chimeric antigen receptor (CAR)-T adoptive cell therapy is one of the most promising advanced therapies for the treatment of cancer, with unprecedented outcomes in haematological malignancies. However, it still lacks ...

    • Cutting-edge: preclinical and clinical development of the first approved LAG-3 inhibitor 

      Chocarro, Luisa Upna Orcid; Bocanegra Gondán, Ana Isabel; Blanco, Ester; Fernández Rubio, Leticia; Arasanz Esteban, Hugo; Echaide Górriz, Míriam; Garnica, Maider; Ramos, Pablo; Piñeiro Hermida, Sergio; Vera García, Ruth; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Immune checkpoint inhibitors (ICIs) have revolutionized medical practice in oncology since the FDA approval of the first ICI 11 years ago. In light of this, Lymphocyte-Activation Gene 3 (LAG-3) is one of the most important ...

    • Descubrimiento de nuevas dianas terapéuticas mediante un sistema de selección racional de líneas tumorales de cáncer de páncreas adaptadas a la inhibición de rutas de señalización 

      Arasanz Esteban, Hugo (2020)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Los objetivos de esta tesis son los siguientes: - Evaluar in vitro los efectos de una inhibición diferencial de cada una de las isoformas de AKT en una línea celular de adenocarcinoma de páncreas metastásico. - Caracterizar ...

    • Enzalutamida como radiopotenciador de líneas celulares de cáncer de próstata 

      Barrado Los Arcos, Marta Upna (2021)   Tesis doctoral / Doktoretza tesia  OpenAccess
      En este trabajo evaluamos el papel de enzalutamida como potenciador de la radioterapia en líneas celulares de cáncer de próstata, sirviendo como experimento de apoyo de investigación básica para investigación clínica. En ...

    • Immune profiling uncovers memory T-cell responses with a Th17 signature in cancer patients with previous SARS-CoV-2 infection followed by mRNA vaccination 

      Echaide Górriz, Míriam; Labiano, Ibone; Delgado, Marina; Fernández de Lascoiti, Ángela; Ochoa, Patricia; Garnica, Maider; Ramos, Pablo; Chocarro, Luisa Upna Orcid; Fernández Rubio, Leticia; Arasanz Esteban, Hugo; Bocanegra Gondán, Ana Isabel; Blanco, Ester; Piñeiro Hermida, Sergio; Morente Sancho, Pilar; Vera García, Ruth; Alsina, María; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      It is unclear whether patients with cancer present inherently impaired responses to COVID-19 and vaccination due to their treatments, neoplastic diseases or both. To address this question, immune profiling was performed ...

    • Leading edge: intratumor delivery of monoclonal antibodies for the treatment of solid tumors 

      Blanco, Ester; Chocarro, Luisa Upna Orcid; Fernández Rubio, Leticia; Bocanegra Gondán, Ana Isabel; Arasanz Esteban, Hugo; Echaide Górriz, Míriam; Garnica, Maider; Piñeiro Hermida, Sergio; Kochan, Grazyna; Escors Murugarren, David (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      Immunotherapies based on immune checkpoint blockade have shown remarkable clinical outcomes and durable responses in patients with many tumor types. Nevertheless, these therapies lack efficacy in most cancer patients, even ...

    • Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions 

      Lachén Montes, Mercedes; Mendizuri, Naroa; Ausín, Karina; Echaide Górriz, Míriam; Blanco, Ester; Chocarro, Luisa Upna Orcid; Toro, María de; Escors Murugarren, David; Fernández Irigoyen, Joaquín Upna Orcid; Kochan, Grazyna; Santamaría, Enrique (Frontiers Media, 2022)   Artículo / Artikulua  OpenAccess
      One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ...

    • Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy 

      Zuazo Ibarra, Miren Upna Orcid; Gato Cañas, María; Llorente, Noelia; Ibáñez-Vea, María Upna Orcid; Arasanz Esteban, Hugo; Kochan, Grazyna; Escors Murugarren, David (AME Publishing, 2017)   Artículo / Artikulua  OpenAccess
      Programmed cell death-1 (PD1) has become a significant target for cancer immunotherapy. PD1 and its receptor programmed cell death 1 ligand 1 (PDL1) are key regulatory physiological immune checkpoints that maintain ...

    • Mrna vaccines against sars-cov-2: advantages and caveats 

      Echaide Górriz, Míriam; Chocarro, Luisa Upna Orcid; Bocanegra Gondán, Ana Isabel; Blanco, Ester; Kochan, Grazyna; Escors Murugarren, David (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      The application of BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 infection has constituted a determinant resource to control the COVID-19 pandemic. Since the beginning of 2021, millions of doses have been administered ...

    • The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity 

      Edwards, Carolyn J.; Sette, Angelica; Cox, Carl; Di Fiore, Barabara; Wyre, Chris; Sydoruk, Daniela; Yadin, David; Hayes, Philip; Stelter, Szymon; Bartlett, Phillip D.; Zuazo Ibarra, Miren Upna Orcid; García-Granda, María Jesús; Benedetti, Giovanni; Fiaska, Stratonik; Birkett, Neil R.; Teng, Yumin; Enever, Carrie; Arasanz Esteban, Hugo; Bocanegra Gondán, Ana Isabel; Chocarro, Luisa Upna Orcid; Fernández, Gonzalo; Vera García, Ruth; Archer, Bethan; Osuch, Isabelle; Lewandowska, Martyna; Surani, Yasmin M.; Kochan, Grazyna; Escors Murugarren, David; Legg, James; Pierce, Andrew J. (Springer Nature, 2021)   Artículo / Artikulua  OpenAccess
      Background: improving cancer immunotherapy long-term clinical benefit is a major priority. It has become apparent that multiple axes of immune suppression restrain the capacity of T cells to provide anti-tumour activity ...

    • Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies 

      Blanco, Ester; Silva-Pilipich, Noelia; Bocanegra Gondán, Ana Isabel; Chocarro, Luisa Upna Orcid; Procopio, Antonio; Ausín, Karina; Fernández Irigoyen, Joaquín Upna Orcid; Fernández Rubio, Leticia; Razquin, Nerea; Igea, Ana; Garnica, Maider; Echaide Górriz, Míriam; Arasanz Esteban, Hugo; Vera García, Ruth; Escors Murugarren, David; Smerdou, Cristian; Kochan, Grazyna (Springer Nature, 2024)   Artículo / Artikulua  OpenAccess
      Background: Previous studies have shown that functional systemic immunity is required for the efficacy of PD-1/PD-L1 blockade immunotherapies in cancer. Hence, systemic reprogramming of immunosuppressive dysfunctional ...

    • El ozono no consigue la desinfección de los vehículos de emergencias de virus similares al SARS-CoV-2 

      Biurrun Cía, Jorge; García Martínez, Begoña Upna Orcid; Pérez Montero, Andrea; Kochan, Grazyna; Escors Murugarren, David; Crespo Martínez, José; Lasa Uzcudun, Íñigo; Echarri Sucunza, Alfredo (SEMES, 2020)   Artículo / Artikulua  OpenAccess
      Ante la pandemia generada por el coronavirus SARS-CoV-2, la desinfección de los vehículos de emergencias supone una cuestión crucial. No en vano, son medio de transporte de pacientes contagiados y podrían ser vector de ...

    • PD-L1 expression in systemic immune cell populations as a potential predictive biomarker of responses to PD-L1/PD-1 blockade therapy in lung cancer 

      Bocanegra Gondán, Ana Isabel; Fernandez Hinojal, Gonzalo; Zuazo Ibarra, Miren Upna Orcid; Arasanz Esteban, Hugo; Garcia-Granda, María Jesús; Hernandez, Carlos; Ibáñez-Vea, María Upna Orcid; Hernandez-Marin, Berta; Martinez-Aguillo, Maite; Lecumberri, María José; Fernández de Lascoiti, Ángela; Teijeira, Lucía; Morilla, Idoia; Vera García, Ruth; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2019)   Artículo / Artikulua  OpenAccess
      PD-L1 tumor expression is a widely used biomarker for patient stratification in PD-L1/PD-1 blockade anticancer therapies, particularly for lung cancer. However, the reliability of this marker is still under debate. Moreover, ...

    • PD1 signal transduction pathways in T cells 

      Arasanz Esteban, Hugo; Gato Cañas, María; Zuazo Ibarra, Miren Upna Orcid; Ibáñez-Vea, María Upna Orcid; Breckpot, Karine; Kochan, Grazyna; Escors Murugarren, David (Impact Journals, 2017)   Artículo / Artikulua  OpenAccess
      The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating ...

    • PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity 

      Gato Cañas, María; Zuazo Ibarra, Miren Upna Orcid; Arasanz Esteban, Hugo; Ibáñez-Vea, María Upna Orcid; Lorenzo, Laura; Fernandez-Hinojal, Gonzalo; Vera García, Ruth; Smerdou, Cristian; Martisova, Eva; Arozarena Martinicorena, Imanol; Wellbrock, Claudia; Llopiz, Diana; Ruiz, Marta; Sarobe, Pablo; Breckpot, Karine; Kochan, Grazyna; Escors Murugarren, David (Elsevier, 2017)   Artículo / Artikulua  OpenAccess
      PDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation through prevention of PDL1-PD1 T cell inhibitory interactions. Here, we find that PDL1 cell-intrinsic signaling protects cancer ...

    • A proteomic atlas of lineage and cancer-polarized expression modules in myeloid cells modeling immunosuppressive tumor-infiltrating subsets 

      Blanco, Ester; Ibáñez-Vea, María Upna Orcid; Hernández, Carlos; Drici, Lylia; Martínez de Morentin Iribarren, Xabier; Gato Cañas, María; Ausín, Karina; Bocanegra Gondán, Ana Isabel; Zuazo Ibarra, Miren Upna Orcid; Chocarro, Luisa Upna Orcid; Arasanz Esteban, Hugo; Fernández Hinojal, Gonzalo; Fernández Irigoyen, Joaquín Upna Orcid; Smerdou, Cristian; Garnica, Maider; Echaide Górriz, Míriam; Fernández Rubio, Leticia; Morente Sancho, Pilar; Ramos-Castellanos, Pablo; Llopiz, Diana; Santamaría, Enrique; Larsen, Martin R.; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Monocytic and granulocytic myeloid-derived suppressor cells together with tumor-infiltrating macrophages constitute the main tumor-infiltrating immunosuppressive myeloid populations. Due to the phenotypic resemblance to ...
      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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